A while ago someone criticized MMF2 users for not including a display option for bilinear interpolation in pixel art games. It's not something I personally am fond of, but is it even possible to do this in MMF2?
There might be a shader that can do it. I know there is an option with Direct X8/9 builds to have the display anti-aliased. Perhaps there are commandline switches that can control it and you could have a launcher?
i recently modified a shader so it could be applied to the entire frame, but the coder needs to do some maths to set the offset. (without the offset, the image resizes from the top left only)
the patch modifies the antialiasing upscale, it adds the parameters fViewportX and fViewportY, they are a factor of the input image size.
a value of 0.5 moves the final image 50% from the top left edge. A negative sign seems to be needed depending on if you're scaling up or down.